The chromatographic properties of SACHTOPORE

Thanks to its unusual property of occurring in the form of a porous solid with a spherical geometry despite its 100 % crystallinity, SACHTOPORE possesses particularly efficient chromatographic separation characteristics.

SACHTOPORE columns achieve a high resolution of, for instance, around 80 000 trays per meter for a 5 µm material (unmodified). Alkaline compounds can also be eluted with extremely good peak symmetries.

SACHTOPORE presents well ordered and chemically homogeneous crystalline surfaces as an ideal interface for adsorptive separation processes. The careful process control applied during production results in an extraordinarily narrow pore-radius distribution and prevents the occurrence of micro-porosity.

Being a refractory, temperature-resistant ceramic oxide, SACHTOPORE is insoluble in acids (up to at least 5 m) and alkalis (up to at least 5 m). SACHTOPORE is therefore significantly more resistant than silica, which dissolves in alkalis as from pH 8 and than aluminium oxide, which, as an amphoteric oxide, is resistant neither to acids nor to alkalis. Use at Alkaline pH values in particular opens up new potential applications here.

The intergrowth of the primary crystals of which the SACHTOPORE particles are composed is extremely pronounced. It imparts to the SACHTOPORE base particles an outstanding mechanical stability. SACHTOPORE materials can be packed into analytical columns with a packing pressure of at least 600 bar and are, thanks to their mechanical stability, also eminently suitable for use in dynamically axially compressed columns in the field of preparative chromatography.

Thanks to its special properties, SACHTOPORE is outstandingly suitable for separation of a large range of compounds which have up to now presented exceptional challenges to chromatography.

Separation of alkaline compounds

The balanced acid/alkali characteristics of SACHTOPORE favour separation and the peak symmetry of "alkaline compounds" in normal-phase chromatography.
Due to their acidic characteristics, classic packing materials such as silica cannot be used in normal-phase chromatography for separation of alkaline compounds, since these substances adsorb irreversibly or are eluted as peaks with a pronounced tailing.

Separation of pharmaceutical compounds

A large number of pharmaceutical substances and other valuable chemical products carry alkaline functions. SACHTOPORE therefore has a particularly high potential in terms of preparative purification of pharmaceutical intermediate and end products on a commercial scale. SACHTOPORE is also in successful use in the field of extraction of natural substances.

Separation of diastereoisomers, positional isomers and substitutional isomers

Thanks to the homogeneous crystalline surface which SACHTOPORE presents to the specimen molecules for adsorption and separation, even the smallest molecular differences in "isomers" can be discriminated.

Applications in the field of pesticides and herbicides

As one would expect with its potential for discrimination of isomers and alkaline compounds, SACHTOPORE is also eminently suitable for use in the pesticides and herbicides sector.